Genetic Variation Within the Interleukin-1 Gene Cluster and Ischemic Stroke
نویسندگان
چکیده
منابع مشابه
Clinical Sciences Genetic Variation Within the Interleukin-1 Gene Cluster and Ischemic Stroke
Background and Purpose—Evidence is emerging that inflammation plays a key role in the pathophysiology of ischemic stroke (IS). The aim of this study was to investigate whether genetic variation in the interleukin-1␣, interleukin-1, and interleukin-1 receptor antagonist genes (IL1A, IL1B, and IL1RN) is associated with IS and/or any etiologic subtype of IS. Methods—Twelve tagSNPs were analyzed i...
متن کاملGenetic variation within the interleukin-1 gene cluster and ischemic stroke.
BACKGROUND AND PURPOSE Evidence is emerging that inflammation plays a key role in the pathophysiology of ischemic stroke (IS). The aim of this study was to investigate whether genetic variation in the interleukin-1α, interleukin-1β, and interleukin-1 receptor antagonist genes (IL1A, IL1B, and IL1RN) is associated with IS and/or any etiologic subtype of IS. METHODS Twelve tagSNPs were analyzed...
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Background and Purpose—PDE4D was identified as the first novel gene associated with ischemic stroke risk. Replication studies have produced conflicting results, but many have been small and underpowered. Meta-analysis provides a method to combine this data and determine in a larger sample size whether the association with PDE4D can be replicated. Methods—A meta-analysis of all PDE4D variants in...
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Background Despite enormous progress in the understanding of human reproductive physiology, the underlying cause of male infertility remains undefined in about 50.0% of cases, which are referred to as idiopathic infertility and already affects about 5.0-7.0% of the general male population. Interlukin- 1 is a regulator that plays an important role in maintaining a safe environment for testes and...
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ژورنال
عنوان ژورنال: Stroke
سال: 2012
ISSN: 0039-2499,1524-4628
DOI: 10.1161/strokeaha.111.647446